If you base a breeding program on dominant factors and performance,
theoretically your affected stock will be strong carriers of the performance
genes that you desire.
The interest in full pigmentation for me began, after first researching
Melanocytes. These are the allelic frequencies that are responsible for the dark
color or spotting of the affected animal.....
In my research, I found it rather odd that where Self color (or total pigmentation) is concerned. Arctic breeds (except possibly the Samoyed) have an absence of incidents where the individual has a lack of white.
To me this was a major concern, as the melanocyte blocks ultraviolet radiation.... Why then, I though, would a breed be absent of individuals, whom had evolved a total protection from ultraviolet breakdown.
My thoughts
immediately turned to the show world, long time poisoner of the canine
evolutionary process.
Early in the development of the Siberian Husky as a "new breed" the Irish
markings and blue eyes were the rage of the show enthusiasts.....
However striking the Irish makings may be, they can not be regarded as the
definition of perfection within the coat of a dog meant to run for days on end
in barren land, where there is little cover from the often blinding sun in
arctic climates.
There is also a high incidents of washed out colors, such as splashy reds, red
pigmented whites, and dogs that have a steady decrease in pigment through the
coarse of their lives....
There is far less frequency in breeding stock for the more dominant coat colors
such as dogs exhibiting Self Coloration, Dark and Wild Agouties, Black Mask
Sables, Sables, and Monochromatically colored dogs.
If a line starts from generic roots and is out crossed to the fullest extent for
maximum heterosis, and then inbred only temporarily to concentrate these dominant
genes and make them prepotent, to then be distributed to dogs expressing a
similar phenotype.
My hopes are that by pairing the presence of the ACE allele with more
heterogynous genes, that the result will be, producing affected stock that more
consistently than not, produces the desired genes, by removing the presence of
inferior gene pairings.
For More Information on Angiotensin-converting enzyme (ACE), click below:
ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight
Link between Gene, Physical Endurance Proven In Research by British Scientists
For More Information on How Dominant Factor Breeding can be used to control variables such as the Angiotensin-converting enzyme (ACE), Click Below:
Mice with Enhanced Macrophage Angiotensin-Converting Enzyme Are Resistant to Melanoma